What happens if you drink on oxyelite pro

Registered as geranamine the DMAA reappeared on the market in as an ingredient in various dietary supplements [ 10 ]. However, several adverse effects began to be associated with the use of products containing DMAA. After these reports, discussions on the origin of DMAA were questioned as to the possibility of this substance be of natural origin or not. Consequently, studies began to investigate geranium plants to identify the presence of DMAA and determine the amount of this substance.

In addition, the amount of DMAA found in plants was lower than the amount found in dietary supplements. However, DMAA has still been found in the general public. Although some studies have already been performed in humans as described, only 1 study was performed in animal model and only 1 study in cell culture [ 6 , 10 ], showing the lack of mechanistic studies. Also, studies showing that those supplements are safe and well tolerated were from groups sponsored by its manufacturer, the USP labs [ 1 , 3 , 17 , 18 ].

On the other hand, those studies showing serious adverse effects associated with OEP consumption were associated with poisoning or ingestion of a huge or unadvertised amount of the supplement. Thus, the aim of this study was to evaluate the effects of known doses of OEP on physical performance, skeletal muscle oxidative stress and metabolism in animal model. OEP dosages were determined in accordance to doses recommended on the label of the OEP: 1 capsule to 70 kg-adult body weight i.

Rats were daily supplemented for 4 weeks. Acute data were obtained 30 min after the first OEP administration while chronic data were obtained after 4 weeks supplementation. The same animals were used in both protocols.

At the end of the experimental period, rats were anesthetized with an i. At the end of the protocol, skeletal muscle soleus and gastrocnemius , heart, liver and adrenal glands samples were surgically removed. Open field test was used to assess spontaneous physical activity as previous published by Rosic et al. At beginning of the test each rat was placed in the center of the arena. Rat movements were recorded by a digital video camera placed centrally above the open field for 5 min and analyzed using AnyMaze software.

Spontaneous physical activity was assessed 30 min after the first OEP administration acute response and 30 min after the last OEP administration at the end of the forth week protocol chronic response. Exercise capacity was determined by graded treadmill exercise test, a method used for detecting exercise intolerance as previous used by our group [ 20 ]. Forty-eight hours after the adaptation period, rats were placed in the exercise streak and allowed to acclimatize for at least 30 min. The ETT was performed following the open field test.

Rats were placed in individual metabolic cages Tecniplast during 48 h for analysis of food and water consumption as previous published by Berger et al. The first 24 h were used for adaptation and the following 24 h were used to record food and water intake. Metabolic cage was performed 30 min after the first OEP administration acute response and 30 min after the last OEP administration at the end of the forth week protocol chronic response. The levels of lipid peroxidation were determined using the thiobarbituric-acid reactive substances TBARS spectrophotometric assay based on the reaction between malondialdehyde MDA and triobarbituric acid TBA as previous described by our group Leal et al.

Briefly, the samples were homogeneized with trichoroacetic acid and butylated hydroxytoluene. After being vortexed, the samples were placed in dry bath and then centrifuged. The upper phase was diluted with triobarbituric acid and placed in dry bath for 30 min, and the upper phase was read at nm using a spectrophotometer.

Additionally, the advanced oxidation protein products AOPP assay protocol was used to evaluate the oxidation of proteins as previous described [ 22 ]. Briefly, samples were diluted with phosphate buffer solution, potassium iodide KI and acetic acid, vortexed for 6 min and then measured at nm. Total protein content was determined by the Bradford method. A standard curve was constructed using stock solution of transaminases and the substrates. All samples of transaminases were measured at nm and GGT was measured at nm.

Mitochondrial to nuclear DNA ratio was used to estimate mitochondrial copy number in skeletal muscle tissue. Statistical software SPSS version No difference was observed in 4. Effect of OEP supplementation on exercise capacity. OEP, Oxyelite Pro. When rats were daily supplemented for 4 weeks with These data suggest a positive effect of acute OEP supplementation but a negative effect on exercise capacity when OEP is administered continuously for 4 weeks chronic.

Spontaneous physical activity was measured using the open field test Fig. No significant difference was observed among groups in any of the parameters analyzed: total running distance Fig. Although not statistically different from Control group, there was a clear tendency to increase spontaneous physical activity after acute OEP supplementation at dose of Effect of OEP supplementation on spontaneous locomotor activity.

OEP is also a well-known dietary supplement for weight loss. Body weight was analyzed throughout the 4 weeks protocol while water and food intake were analyzed during the first 24 h after the first OEP administration acute and during 24 h after the last week of the chronic administration protocol Table 1. Body weight was not different among groups at the beginning or at the end of the protocol Table 1. In agreement, no difference in food or water intake was observed among groups after acute administration or after 4 weeks OEP supplementation measured by the metabolic cage Table 1.

Altogether there is no evidence that either acute or chronic OEP supplementation inhibits appetite or aids to decrease body weight at least in normal feed rats. Also, at the end of the chronic protocol 4 weeks , gastrocnemius Control, 4. Cases of acute hepatitis and liver injury were related to the use of OEP, however the amount of OEP ingestion was reported as unknown or at high doses [ 4 , 5 , 23 ].

Effect of OEP supplementation on liver injury markers. Effect of OEP supplementation on circulating and tissue oxidative stress markers. However, they are widely available in the U. Canadians may have purchased these products while shopping online or travelling. Several dozen U. Symptoms of liver injury can include fever, fatigue, loss of appetite, nausea, vomiting, abdominal pain, dark urine, clay or gray-colored bowel movements, joint pain, yellow eyes, and jaundice.

In fact, there's only 6 naturally-found compounds that do all of this amazing work! We explain the science behind OEP in terms that you can understand, and link to real scientific studies backing its ingredients.

From YouTube to Facebook to Twitter to homemade blogs, you can see how just about everyone is doing so well with OEP -- ranging from competitive athletes to "gym junkies" to postpartum women to the members of the military Check out these pics and testimonials for motivation!

Food Comes First First, we are obliged to tell you that food comes first. If you are not eating right, then ANY supplementation plan we give you is destined for failure. We assume that you have your diet down and are actively monitoring it. Click Here to get even more information on Oxy Elite, including more deals, diet tips, fitness programs, and more!

Of those, 36 used OxyElite Pro. Hepatitis is a liver disease, with symptoms that include fatigue, fever, nausea, jaundice and diarrhea.

The Aloha State may be especially sensitive to detecting severe hepatitis outbreaks because only one hospital in the state can handle acute liver failure and transplants. That hospital also happens to be across the street from the state health department, Park said.